RNA Details
Disease Name
acute myocardial infarction
Tissue
heart
RNA Symbol
CircUbe3a
RNA ID
RNA Type
circRNA
Alteration Pattern
up regulation
Species
mus musculus
Detection Methods
qRT-PCR;RNA immunoprecipitation (RIP);dual-luciferase reporter assays
Target
miR-138-5p;RhoC
Pathway
NA
PubMed ID
Title
CircUbe3a from M2 macrophage-derived small extracellular vesicles mediates myocardial fibrosis after acute myocardial infarction
Year
2021
Function
"M2M-derived circUbe3a-containing small extracellular vesicles promote the proliferation, migration, and phenotypic transformation of cardiac fibroblasts by directly targeting the miR-138-5p/RhoC axis."